Array CGH

Crete Fertility Centre is one of the very few centres in Greece which perform the new method, Array-CGH (Array Comparative Genomic Hybridization) – PGS (Preimplantation Genetic Screening), with excellent results.

Array CGH (PGS) is the only method able to detect unbalanced chromosomal abnormalities. This is because balanced chromosomal abnormalities such as reciprocal translocations, inversions or ring chromosomes do not affect copy number, which is what is detected by CGH technologies. CGH enables the exploration of all 46 human chromosomes in single test and the discovery of deletions and duplications, even on microscopic scale which may lead to the identification of candidate genes to be further explored by other cytological techniques.

Array CGH (PGS) can help in cases of advanced maternal age, multiple miscarriages and failed embryo transfers.

Humans generally have 46 chromosomes that come as 23 pairs, one of each pair from our Mum and one of each from our Dad. Problems arise when an embryo misses out on a chromosome or picks up an extra one – that’s called a chromosomal abnormality.

Chromosomal abnormalities can cause your embryo to fail to implant or miscarry or they might result in a baby born with developmental problems or a serious genetic condition.
This test checks all chromosomes to see if an embryo has a balanced set, checking specifically for:

  • aneuploidy (chromosome abnormality): a frequent cause of unsuccessful IVF attempts, miscarriages and abnormal live births
  • translocations: looking for unbalanced parts/sets of chromosomes
  • medical sex selection: tells us whether the embryo is male or female which allows genetic disease risk reduction in such cases

Crete Fertility Centre’s scientists have helped hundreds of families achieve their dream, taking home healthy babies.

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