Ovarian Boost IV is a specialized preparation before ovarian rejuvenation treatments such as PRP, Stem Cells and Exosomes treatment.

Ovarian Rejuvenation, Stem cells and Exosomes treatment– or a combination of all these – are innovative therapeutic approaches aimed at improving ovarian function through the growth factors released from the patient’s own platelets and adipose tissue. This method harnesses the body’s intrinsic regenerative capacity, supporting cellular repair and renewal.

For the ovaries to respond optimally, the body must be in a state of nutritional sufficiency and cellular readiness. Research indicates that strong antioxidant defense and adequate levels of essential micronutrients contribute to improved oocyte quality and enhanced response to assisted reproduction treatments.

The Ovarian Boost IV, provided at the Crete Fertility Centre in collaboration with Jovian Health Lab, is a specialized intravenous protocol administered prior to the rejuvenation treatments. Its goal is to create a favorable microenvironment in the ovaries by reducing oxidative stress, enhancing mitochondrial energy production, and supporting hormonal balance. In this way, the rejuvenation treatments are performed in a system that has already activated its natural defense and renewal mechanisms, thereby increasing the likelihood of improved oocyte quality and quantity.

How Ovarian Boost IV works

• Antioxidant protection
  Reduces oxidative damage and supports DNA integrity in ovarian cells. Increased antioxidant capacity has been associated with better oocyte quality and higher fertilization rates.
• Mitochondrial support
  Mitochondria are the “energy centers” of oocytes. When functioning optimally, they fuel the cellular processes required for oocyte maturation and viability. Factors enhancing mitochondrial function are linked to improved embryo quality and treatment response.
• Hormonal balance
  The supply of key micronutrients contributes to the regulation of the endocrine system. A stable hormonal profile is a critical determinant of reproductive success.
• Cellular regeneration
  Establishes the conditions for a stronger response to the growth factors of PRP, as ovarian cells are already supported with the necessary elements for repair and renewal.

Comprehensive approach

The Ovarian Boost IV provides women undergoing rejuvenation treatments with the assurance that they are approaching the procedure in the most complete way possible. When the body is in a state of nutritional sufficiency, reduced inflammation, and enhanced mitochondrial function, at rejuvenation treatments can perform at its full potential.

Choosing this preparation is not only a medical intervention; it represents a comprehensive strategy to support reproductive health and optimize the ovarian response to rejuvenation treatments.

Timing of Ovarian Boost IV administration

The Ovarian Boost IV is recommended one day before the rejuvenation treatment. Some women choose to undergo 2–3 sessions during the preceding week for more comprehensive preparation. In addition, administration is also recommended after the rejuvenation treatment, to support tissue recovery and sustain the regenerative effects.

Advanced Fertility Preparation Protocol – Comprehensive individualized preparation

The Advanced Fertility Preparation Protocol is designed for women who wish to maximize their body’s response before and after ovarian rejuvenation. It is an individualized medical process tailored to each woman’s metabolic and hormonal profile, combining nutritional guidance, targeted supplement support, and, when indicated, functional testing.

Individualized nutrition

Nutrition plans are tailored to the specific needs of each patient and do not follow general dietary models. The goals are:

• strengthening antioxidant defense and cellular protection,
• reducing low-grade inflammation that can impair hormonal function,
• improving immune system regulation,
• supporting gut health and the microbiome, which are essential for nutrient absorption and estrogen metabolism.

Individualized supplementation

Supplementation protocols are customized based on deficiencies, biochemical characteristics, and the specific needs of each patient. Their objectives are:

• correcting nutritional insufficiencies,
• enhancing mitochondrial function and energy production,
• stabilizing hormonal balance,
• preparing the cellular environment for optimal response to PRP growth factors.

Functional testing 

For women seeking a more comprehensive assessment, the following indicative tests may optionally be performed:

• Methylation Profile: evaluation of DNA repair capacity and energy metabolism.
• Food Intolerance Testing: detection of intolerances associated with chronic inflammation and endocrine disruption.
• Gut Microbiome Mapping: analysis of the microbiome for improved nutrient absorption, immune balance, and hormonal metabolism.

These tests are not mandatory and may be performed optionally in the patient’s country of residence. The medical team may also recommend additional specialized assessments depending on the individual profile.

Clinical significance of preparation

Individualized preparation before ovarian rejuvenation treatment contributes to:

• Optimization of the ovarian microenvironment, enhancing the response to growth factors.
• Reduction of oxidative stress and inflammation, which negatively affect oocyte quality.
• Strengthening of immune function, closely linked to implantation and fertility outcomes.
• Stabilization of hormonal balance, essential for oocyte maturation and ovarian function.
• Support after ovarian rejuvenation, promoting recovery and sustaining the beneficial effects of the therapy.

Oversight and coordination of Ovarian Boost IV

Crete Fertility Centre works in close collaboration with the medical team of Jovian Health Lab ensuring a comprehensive and scientifically grounded preparation. Every stage – from intravenous therapy to individualized nutrition, supplementation, and optional testing – is carefully designed and coordinated to maximize the effectiveness of the rejuvenation treatments and the overall success of the fertility journey.