Recurrent Implantation Failure (RIF) – Biopsy/Scratch or Hysteroscopy
Some women undergoing IVF treatment fail to conceive despite several attempts with good-quality embryos and no identifiable reason. We call this ‘recurrent implantation failure’ (RIF) where the embryo fails to embed or implant within the lining of the womb. Studies have shown that inducing injury to the lining of the womb in the cycle before starting ovarian stimulation for IVF can help improve the chances of achieving pregnancy. Injury can be induced by either scratching the lining of the womb using a biopsy tube or by hysteroscopy.
Crete Fertility Centre incorporate this treatment for the “recurrent implantation failure” (RIF), where the embryo fails to embed or implant within the lining of the womb. Studies have shown that inducing injury (Biopsy/Scratch or Hysteroscopy) to the lining of the womb in the cycle before starting ovarian stimulation for IVF is 70% more likely to result in a clinical pregnancy as opposed to no treatment.
Bibliography : Potdar N, Gelbaya T, Nardo LG. Reproductive BioMedicine Online 2012; 25(6): 561-571.
Grant of Lipoproteinis
An important new method is the use of Lipoprotein in couples who experience repeated failed attempts implantation. After studies in women presenting with infertility after use intravenous solute Lipoprotein, suppression was observed in the activity of NK (Natural Killer) cells at physiological levels from the first week. These results demonstrate that the use Lipoprotein can be successfully used as a therapeutic way to regulate the function of NK cells in women with reproductive failures.
Intrauterine injection of human chorionic gonadotropin (HCG)
Successful implantation after in vitro fertilization (IVF) and embryo transfer (ET) depends on several factors related to embryo quality and the receptivity of the endometrium. It is estimated that approximately 50% to 75% loss of pregnancy after in vitro fertilization – embryo transfer due to implantation failure. Following clinical and laboratory studies observed that intrauterine infusion of human chorionic gonadotropin (HCG) before embryo transfer significantly improves the implantation success and significantly increases pregnancy rates after IVF.
Bibliography : Ragaa Mansour,Nevine Tawab, B.Sc., Omnia Kamal, B.Biomed., Yahia El-Faissal, M.D.,Ahmed Serour, M.D., Mohamed Aboulghar, M.D., Gamal Serour, M.D. Fertility and Sterility, Volume 96, Issue 6, December 2011, Pages 1370-1374.e1
These innovative techniques are important in the prevention of miscarriages and to avoid repeated failed attempts of implantation. Also, for the successful and safe result the biggest role is played by the well-qualified and well-informed physician who will direct the couple to take the right decisions to successfully bring to life the next generation.